All good things must come to an end, including Torrey DeVitto and Yaya DaCosta’s time on Chicago Med.

After six seasons, DeVitto, 36, and DaCosta, 38, are leaving their longtime roles on the series as Dr. Natalie Manning and Nurse April Sexton, respectively, PEOPLE confirms. Following Deadline’s initial report about the casting shakeup on Wednesday, both DeVitto and DaCosta subsequently announced their departures via Instagram.

In DeVitto’s post, she acknowledged the fond experience she had from being a part of the NBC hit.

“It has been such an honor and pure joy to bring Dr. Natalie Manning to life for all of you on Chicago Med for the past 6 seasons,” she wrote, sharing photos of herself in character. “But it is now time for her and me to bow out and say goodbye.”

The Vampire Diaries alum added, “Thank you to all you loyal watchers who adored her as much as I did. I can’t wait to share what’s to come with all of you. New adventures await! With love and gratitude, Torrey ❤️.”