Mayim Bialik is reflecting on the significance of her guest hosting spot on Jeopardy!.

On Monday, Bialik, 45, will become the latest guest host to take over at the podium after the death of beloved host Alex Trebek last year.

In a Jeopardy! interview posted Saturday, the Big Bang Theory alum, who has her PhD in neuroscience from UCLA, said it was an “immense honor” to stand in Trebek’s place.

“This is such an iconic and unbelievable piece of our collective culture, to be considered to be part of it really in any way, it’s an immense honor,” she said. “Especially for someone who’s dedicated so much of my life to academia to knowing things and to being able to communicate things.”

As for what she hopes to bring to the role, Bialik noted her background as a woman in academia.

“Being a woman of science, as I am, is something that I’m obviously very passionate about presenting myself as,” she explained. “I really didn’t grow up with a lot of female role models and I think especially for young people — not just young girls, but for young girls and boys — to see that women can be scientists and can do these types of intellectual things, that feels very important to me.”

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