New approach could offer a more accurate way to evaluate donor kidney  quality

A new way to evaluate the quality of kidneys before transplantation could one day help increase the number of usable donor kidneys. The method uses highly sensitive spectroscopy analysis to detect biomarkers related to kidney injury, which could also be useful for diagnosing kidney problems in patients.

“Today, the lack of methods for precisely measuring donor kidney injury and predicting transplant outcome leads to high discard rates and recipient complications in clinical practice,” said research team leader Mingxing Sui from Changhai Hospital of Shanghai in China.

“We want to solve this problem by developing a new system that can noninvasively provide an objective measure of donor kidney quality.”

In the Optica Publishing Group journal Optics Express, Sui and colleagues from the University of Shanghai for Science and Technology in China report the first use of surface-enhanced Raman scattering (SERS) for simultaneous, ultrasensitive detection of two important kidney injury biomarkers. They also describe how they made SERS spectroscopy more practical for clinical use.

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